|
KMID : 0861020070220010111
|
|
Korea Journal of Herbology
2007 Volume.22 No. 1 p.111 ~ p.117
|
|
|
Anti-inflammatory effect of extract of Pulsatilla koreana $N_{AKAI}$ in LPS-stimulated Murine peritoneal macrophage
|
|
Park Sung-Joo
Song Ho-Joon
|
|
|
Abstract
|
|
|
Objectives : The purpose of this study was to investigate the anti-inflammatory effects of extract from Pulsatilla koreana N_{AKAI} (PK) on the peritoneal macrophage.
Methods : To evaluate of anti-inflammatory of PK, we examined cytokines and NO production in lipopolysacchride (LPS)-induced macrophages. Furthermore, we examined molecular mechanism using western blot.
Results : 1.Extract from PK reduced LPS-induced NO, tumor necrosis factor-a (TNF-{alpha}), interleukin (IL)-6 and IL-12 production in peritoneal macrophages. 2.Extract from PK itself does not have any cytotoxic effect. PK inhibited the activation of extracelluar signal-regulated kinase(ERK 1/2) but not another mitogen-activated protein kinases (MAPKs) such as p38, c-Jun NH2-terminal kinase (JNK) and the degradation of inhibitory kappa B a (I_{k}B_{a}) does not any effect in the LPS-stimulated peritoneal macrophages.
Conclusion : PK down-regulated LPS-induced NO and cytokines production, which may be provide a clinical basis for anti-inflammatory properties of PK.
|
|
|
KEYWORD
|
|
|
Pulsatilla koreana N_{AKAI} (PK), lipopolysaccharide (LPS), anti-inflammation, mitogen-activated protein kinases(MARK)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|